Tuberculosis (TB) continues to be a major public health concern, particularly in developing nations. It is caused by Mycobacterium tuberculosis and primarily affects the lungs, although other organs may also be involved. This review highlights the epidemiological trends, clinical manifestations, and the impact of TB on the quality of life (QoL) of affected individuals. The disease exerts a multidimensional burden, including physical debilitation, psychological distress, and social challenges such as stigma and economic hardship. Effective control of TB requires early diagnosis, sustained treatment adherence, and comprehensive patient support. Addressing these factors is essential to improve overall health outcomes and quality of life.