This study aimed at establishing the relationship between dermatoglyphic patterns and academic performance of students in Madonna University. A total of 200 students voluntarily participated in this study which was selected randomly. Validated questionnaire was distributed to the students, and their right and left hand fingerprints were collected simultaneously using digital scanning method. The data were tested using mood median test, Pearson Chisquare analysis of association and fitness regression model. The mood’s median test of the result showed that the differences in the median score for the different patterns and academic patterns were not significant for the entire right digit (p>0.05) while for the left, all the digits were not showing differences in the patterns and academic performance except the left index digit (p<0.05). Also, the test of association between finger patterns and academic performance was observed to be significant only in the right little finger while the left fingers showed no significant association between the variables. The study also showed no significant difference between ATD angle and academic performance of Madonna University students as Regression Model (R-square value) at zero indicate no accuracy in the prediction (P>0.05). In conclusion this study has shown that there is significant association between finger patterns (especially right little finger and left index finger) and academic performance. However, ATD angle on the other hand did not show any significant difference with academic performance among the students. This implies that while finger patterns may be used to predict academic performance, ATD angle on the other hand may not serve a better tool in predicting academic performance among Madonna University students.