Background: single pill combinations is proved to achieve patient compliance and hence better blood sugar control and less occurrence of complications of type two diabetes. Objectives: to assess the outcome of fixed dose combination management of diabetic patients by monitor blood glucose and HbA1c, renal function test and body weight, and test its significancy in regard to the previous management. Methodology: Prospective follow up study carried out for a period of 28 weeks, combined pills of pioglitazone 30mg with glyburide 2mg as a single dose drug taken before breakfast-and dapagliflozin 10mg combined with 1000mg metformin as a single dose taken at dinner, measurement of fasting blood sugar, HbA1c, blood urea , creatine and weight and renal function test and weight were done at the start of the study and then repeated 28 weeks later, compliance was assessed using Morisky Medication Adherence Scale (MMAS-8) with 3 level Likert scale. Results: The eligible subjects who were involved in the study were 72, their mean blood sugar and HbA1c at start of the study was 302.09, 10.40respectively, mean blood urea and creatinine 41.34, 0.72respectively, mean weight was 80.03 kg, by the end of the study period all the reading was reduced to the following levels: , 198.33, 8.43, 40.67, .69 in the same previous order, apart from the mean weight which showed an increase to 81.82. While compliance was increased from score of 6 up to score of 8. Conclusion: Drug combination and single pills have assured compliance and hence blood sugar control and have a negative impact on the occurrence of complications.