Background: Surgical site infection (SSI) and wound complications continue to constitute one of the most significant causes of morbidity after pediatric cardiac surgery. New prevention methods, standard care bundles, and negative pressure wound therapy (NPWT) have been developed to enhance postoperative outcomes. Purpose: This systematic review article aims to determine evidence published over the past 10 years on wound management strategies after cardiac surgery in children, including their prevention, treatment, and outcomes. Methods: A systematic literature search was conducted in PubMed, Scopus, and Web of Science for studies published between January 2016 and March 2025. Articles that focused on wound prevention, surgical site infections, sternal wound care, or NPWT in children's cardiac surgery were incorporated. Results: Fifteen studies involving over 3,000 pediatric cardiac surgery patients were included. Implementation of standardized prevention bundles resulted in a 30–70% reduction in SSI rates, while NPWT achieved wound closure success exceeding 85% in cases of deep sternal wound infection and mediastinitis. Conclusion: Standardized cardiac pediatric wound management interventions based on prevention bundles and early administration of advanced wound therapies are most likely to be effective following pediatric cardiac surgery. The strategies play a crucial role in minimizing morbidity and enhancing recovery among pediatric patients.