Medical devices have become indispensable in modern healthcare settings, fundamentally transforming clinical workflows and patient care delivery. However, despite significant technological advancements, the integration of medical devices into healthcare environments presents multifaceted challenges that directly impact both healthcare worker quality of life and patient safety outcomes. This comprehensive review synthesizes recent literature examining the relationship between medical device usability, human factors engineering principles, and the well-being of healthcare professionals including radiological technicians, health informatics specialists, nurses, clinical coding technicians, and health administration staff. The review examines critical factors including device usability design, ergonomic considerations, training adequacy, workflow integration, and psychological impacts including burnout and job satisfaction. Evidence demonstrates that while medical devices offer substantial benefits in terms of efficiency, accuracy, and clinical decision support, their implementation frequently encounters significant barriers related to poor usability, inadequate training, ergonomic challenges, and psychological stress among users. Key findings indicate that healthcare systems exhibiting structured training programs, user-centered design principles, and adequate organizational support demonstrate markedly superior outcomes in staff satisfaction, productivity, and patient safety. This review identifies essential strategies for optimizing medical device integration, including comprehensive human factors engineering evaluation during development, iterative usability testing with end-users, enhanced training protocols, workflow-centered design approaches, and institutional commitment to supporting staff adaptation and well-being during technology transitions.