The study aimed to evaluate donor deferrals among individuals presenting for whole blood or platelet apheresis donation at King Abdullah Medical City in Makkah, Blood Bank Department, and to classify deferrals by screening stage. Category 1 deferrals included interview-based reasons such as recent travel to malaria-endemic areas, current medication use, or behavioral risk disclosures. Category 2 deferrals included clinical assessment findings such as low hemoglobin, abnormal blood pressure, and high body temperature. The study also evaluated the theoretical potential of telemedicine to reduce Category 1 deferrals through pre-donation screening. A retrospective cross-sectional study was conducted at the Blood Bank Department of King Abdullah Medical City in Makkah between January 2023 and December 2024. From 3,029 recorded deferrals, a systematic random sample of 385 deferred donors was selected for analysis. Each deferral was classified according to the screening stage. Descriptive statistics and Chi-square tests were used. A total of 385 deferred donors were analyzed. Of these, 260 (67.5%) were classified as Category 2 and 125 (32.5%) as Category 1. Gender was significantly associated with deferral category (χ²(1, N = 385) = 6.128, p = 0.013). Category 1 deferrals were more frequent among male donors (35.2%) than female donors (18.0%). Interview-based factors accounted for 32.5% of deferrals and could be identified in advance through structured remote screening methods such as tele-interviews, reducing the likelihood of unnecessary on-site visits. The study examined the theoretical role of telemedicine as a pre-donation triage tool, emphasizing its potential to decrease avoidable deferrals and strengthen donor retention through targeted early interventions.