The review paper explains the effects of data-driven transformation in healthcare on access to care and efficiency in the southwest part of Saudi Arabia, with focus on Jazan. Within the ambit of Saudi Vision 2030, several steps have been taken by the Kingdom to adopt digital health technologies that will help close the urban-rural healthcare gap. Utilization of telemedicine, mobile health applications, and AI-enabled diagnostics continues shaping much-needed changes in health delivery mechanisms in resource-poor areas by enhancing access to medical services for previously underprivileged rural populations alienated by geographical barriers, long travel distances to health facilities, unaffordable costs, and inadequate availability of both health facilities and personnel. Across the southwest of Saudi Arabia, where terrain and infrastructural challenges have historically obstructed access to healthcare, digital health initiatives like Seha Virtual Hospital (SVH), and Sehhaty App now play a crucial role in availing remote consultations, the management of chronic diseases, and delivery of care. The integration of electronic health records (EHR) and, in turn, AI tools will boost the efficiency of healthcare services through real-time data sharing, better allocation of resources, and lesser diagnostic errors. Yet, several challenges remain, including issues of internet connection in the rural space, digital literacy, preparedness of the workforce, and regulatory frameworks for telemedicine. These barriers need to be dealt with for the sustainable and equitable rollout of digital health solutions. This review elaborates on how data-driven transformation of healthcare could precipitate a favourable outcome in the health of the southwest region while laying down the challenges to be surmounted for this progress to continue with success. By and large, the data-driven health transformation in southwest Saudi Arabia presents a potential model for addressing disparities between urban and rural health, resulting in more efficient, accessible, and patient-centred care.