Illicit trade is a global phenomenon that undermines public security, erodes legitimate business activity, jeopardizes public health, threatens biodiversity and ecosystems, and deprives governments of the necessary resources to finance investments projects. International trade law provides an effective legal and enforcement mechanisms to combat illicit trade. This work seeks to examine the role of international trade law adopted by Cameroon at the international, regional and national levels, and their contribution towards combatting illicit trade. At the international level, it focuses principally on international trade law adopted under the auspices of the World Customs Organisation’s Revised Kyoto Convention of 2006 and the SAFE Framework of Standards of 2005. The reason being that the World Customs Organisation’s legal instruments offer a strong framework to combat illicit trade. This paper identifies the various challenges inherent in implementation, and concludes that compliance with the adopted international trade norms can go a long way to combat illicit trade. This work employs a doctrinal research methodology based on primary and secondary sources of data and empirical based on Focused Group Discussion.