Cross-border cooperation today is considered as a pivotal element in addressing contemporary challenges such as drugs trafficking, smuggling, terrorism, and transnational organized crimes across international borders. It is believed that no country can unilaterally ensure the security of it borders alone without cooperation between countries that share a common border. The institution of a one stop border post between Cameroon and Nigeria at their joint borders in Ekok and Mfum is considered as a sign of cooperation existing between the two countries. Various legal mechanisms have been developed by International Organisations seeking to advocate for cross-border cooperation as a sine qua non factor in ensuring border security. This paper focuses principally on the World Customs Organization’s concept of Coordinated Border Management which is anchored on cross-border cooperation as a legal mechanism in mitigating customs risks. It examines some practical dimensions of cross-border cooperation between customs administrations and other border agencies at the domestic and across the border, and their possible role towards ensuring border security at Ekok and Mfum. This work concludes that compliance with some of the key principles governing cross-border cooperation such as joint border security patrol, intelligence sharing, joint capacity building, use of common facilities, and memoranda of understanding, information technology, will go a long way to mitigate customs risks. This work employs both a doctrinal research methodology based on content analysis of primary and secondary data, as well as empirical research methodology based on focused group discussion.