Patient management of chronic and subacute dorsal pain may be difficult, especially in cases when the patient does not respond to traditional pharmacologic treatment. It has just come to light that the erector spinae plane block is a potentially useful interventional approach for the treatment of regional pain. In patients who were suffering from subacute and chronic dorsal pain, the purpose of this research was to determine whether or not erect spine plane prolotherapy was helpful in significantly lowering pain across a variety of thoracic levels. All of the patients who had undergone erect spine plane prolotherapy at thoracic levels T1–T12 were included in the prospective review that was carried out. Both subacute (pain that lasted for less than three months) and chronic (pain that lasted for more than three months) pain groups were assigned to patients. At baseline, on the first day, one week, and one month after the surgery, the Numeric Rating Scale (NRS) was used to evaluate the levels of pain experienced by the patients. In addition, the amount of injection and the block laterality (unilateral vs bilateral) were measured simultaneously. The majority of patients had chronic dorsal pain (n = 173), with T5–T8 and T1–T4 being the most commonly targeted levels. Bilateral erect spine plane prolotherapy were predominantly utilized in chronic cases. Both groups demonstrated substantial pain reduction. In the subacute group, mean NRS scores decreased from 8 at baseline to 2 at one month (75% improvement). Similarly, the chronic group experienced a reduction from 7 to 2 (71% improvement). Prolotherapy performed on the erect spine plane was able to offer considerable and long-lasting pain alleviation in patients suffering from subacute and chronic dorsal pain. The approach was successful at a number of different thoracic levels and has the potential to be a viable option for the therapy of long-term pain, particularly in chronic instances that need bilateral intervention.