Ocular and oral health are fundamental components of systemic well-being, intricately linked through a complex network of shared risk factors, overlapping inflammatory pathways, and common systemic diseases. Recent advances in biomedical research have increasingly illuminated the bidirectional relationships between these two seemingly distinct anatomical regions, revealing that disturbances in one often reflect or exacerbate pathology in the other. For example, chronic systemic conditions such as diabetes mellitus, cardiovascular disease, and autoimmune disorders manifest with both ocular and oral complications, underscoring the necessity for integrated healthcare approaches. The convergence of ocular and oral health domains necessitates a cross-disciplinary framework that actively involves dentists, pharmacists, and optics technicians to optimize patient outcomes through early detection, comprehensive management, and patient-centered education. Dentists play a pivotal role by identifying oral manifestations indicative of systemic and ocular diseases, managing oral conditions that may influence ocular health, and facilitating timely referrals. Pharmacists contribute critical expertise in medication management, addressing challenges related to polypharmacy, drug-induced adverse effects affecting both the eyes and oral cavity, and ensuring therapeutic adherence. Optics technicians serve as essential facilitators of vision care, conducting preliminary ocular assessments, assisting in the early detection of ocular abnormalities, and collaborating with other healthcare professionals to manage systemic conditions with ocular manifestations. This review synthesizes current scientific evidence elucidating the interconnections between ocular and oral health, delineates the distinct yet complementary roles of these healthcare professionals within an integrated care framework, and discusses existing challenges and future directions for fostering effective interdisciplinary collaboration. By embracing such cross-disciplinary approaches, healthcare systems can move towards more holistic, patient-centered models that improve diagnostic accuracy, therapeutic efficacy, and overall quality of life for individuals affected by complex, multisystem diseases.