Introduction: Neonatal lupus (NL) is a transient disease linked to the transplacental passage of maternal autoantibodies, mainly anti-SSA/Ro and sometimes anti-SSB/La. It manifests mainly by predominantly cutaneous forms and a prognosis dependent on cardiac involvement. Observation: We report the case of a four-week-old girl, born at term (37 weeks + 4 days, weight 2.9 kg), who presented since birth with hypopigmented periorbital macules in a vespertilio pattern. Her 36-year-old mother presented with bilateral inflammatory arthralgias with synovitis of the wrists that had been developing for six months. The infant's clinical examination was normal, the electrocardiogram and echocardiography showed no abnormalities, and neonatal laboratory tests were non-contributory. Maternal ANA was 1/800, anti-SSA/Ro were positive in both mother and child, while anti-SSB/La and anti-U1RNP were negative. The diagnosis was neonatal cutaneous lupus erythematosus in the child and systemic lupus with isolated articular expression in the mother. The treatment combined photoprotection and topical hydrocortisone for the infant, and low-dose prednisone and hydroxychloroquine for the mother. At 1 month, the infant's skin lesions completely regressed without sequelae, the ECG remained normal, and the maternal pain had disappeared. Conclusion: This case highlights the diagnostic interest of photosensitive facial eruptions and the importance of joint management of the mother and child, as well as systematic cardiovascular monitoring of newborns exposed to anti-SSA/Ro.