Background: Female sexual health is often underexplored in the context of chronic liver diseases, despite its key role in overall quality of life. Sexual dysfunction in this population is rarely addressed during hepatology consultations, even though it may be aggravated by clinical complications such as cirrhosis. Methods: This was a cross-sectional, descriptive, and analytical study conducted between January and December 2024, including 106 female patients (53 with chronic liver disease, 53 controls). All completed the FSFI questionnaire. A score < 26 indicated sexual dysfunction. Data were analyzed using Jamovi version 2.2.5. Results: Sexual dysfunction (FSFI score < 26) was observed in 60.4% of patients with chronic liver disease, versus 28.3% in the control group (p < 0.001). The most affected domains were lubrication (84.4%), satisfaction (75%), and desire (65.6%). Cirrhosis was significantly associated with dysfunction (OR = 6.8; p = 0.046). Conclusion: Sexual dysfunction is frequent in women with chronic liver disease, especially in those with cirrhosis. Despite its high prevalence, it remains neglected in routine hepatology practice, underscoring the need for integrated sexual health assessment.