To study the prescribing pattern of drugs used in Diabetes mellitus with cardiovascular diseases in a tertiary care hospital. A prospective observational study was done in the General Medicine department of Almas Hospital for 6 months to analyze the prescribing pattern of drugs used in Diabetes mellitus with cardiovascular diseases. 154 patient prescription patterns were studied, out of which 56.5% were males and 43.5% were females. Most of the patients were in the age group of 41-64. Hypertension was the most commonly found co-morbid condition. Glimepiride+metformin were mostly prescribed during a hospital stay. Metformin was the commonly prescribed oral hypoglycemic agent. It was found that the majority of drugs were prescribed from the recent NLEM of India by the practitioners which indicates the implementation and adoption of national drug policy by the hospitals and cardiologists