Background: Oral diseases remain a significant global health burden. The traditional restorative approach to dental care, focused on repairing disease outcomes, is increasingly recognized as insufficient for managing these chronic, multifactorial conditions. This highlights a critical need for a more preventive and holistic paradigm. Objective: This review aims to synthesize the current evidence on key dietary and pharmacological adjuncts that supplement and enhance standard mechanical dental care. Furthermore, it seeks to critically analyze the essential role of interprofessional collaboration (IPC) in the effective implementation of these adjuncts to optimize patient outcomes and facilitate a shift towards comprehensive, patient-centered oral healthcare. Methods: A comprehensive literature search was conducted across multiple electronic databases, including PubMed, Scopus, and Web of Science, for articles published up to June 2025. The review prioritized systematic reviews, meta-analyses, randomized controlled trials, and authoritative position papers. Findings: The evidence strongly supports the efficacy of various pharmacological adjuncts, including topical fluorides for remineralization, chlorhexidine for short-term microbial control, and sub-antimicrobial dose doxycycline for host modulation in periodontitis. Dietary adjuncts, such as polyphenols, probiotics, and dietary nitrates, show promising potential in modulating the oral microbiome and host response. The synergistic potential of these adjuncts is most effectively realized when managed by a cohesive interprofessional team. This collaborative model, involving dentists, physicians, pharmacists, and dietitians, allows for comprehensive management of interconnected factors such as systemic disease, polypharmacy, and complex nutritional needs. Conclusion: The integration of evidence-based dietary and pharmacological adjuncts through a structured interprofessional collaborative model is fundamental to advancing modern dental care.