The ancient sages provided extensive information about the causes of ailments and even detailed the possibility of hereditary transmission channels and methods for curing them. Ayurveda is a natural medicine system that was developed in India over 5,000 years ago and uses herbs and other materials to treat health issues. Examining the contributions of ancient Indian medical scientists Sushruta, Charaka, and Patanjali is the study's main goal. Method: The study is descriptive in nature and is mostly based on information gathered from books and other secondary sources like journals, Hindu scriptures, and online search engines like e-libraries, e-books, e-articles, and different website-based information, reference materials, wikipedia, Buddhist writings, medical related ancient books, stories of Greek travelers to India, ancient scriptures, etc. Results: Indian medical knowledge travelled over the world and was retained in certain regions where it was used in a modified form while maintaining its originality. In conclusion, Sushruta, Charaka, and Patanjali had a major influence on India's medical systems in antiquity. Their important findings and innovative theories still have an impact on how we advance medical procedures.