Out of all the several types of gastro-retentive drug delivery systems, floating drug delivery is thought to be the most efficient and effective system. Enhancing the bioavailability of medications with a stomach absorption window is mostly dependent on two key parameters: short gastric residence times (GRT) and variable gastric emptying times (GET). The floating drug delivery method is a low-density system that can be either non-effervescent or effervescent, but it must have enough buoyancy to pass over the contents of the stomach and stay buoyant there for an extended period of time without slowing down the stomach's rate of emptying. Drugs that are unstable in the lower intestine environment, have a limited absorption window in the upper gastrointestinal tract, are lowly soluble at higher pH levels, and are active locally can be delivered via the floating drug delivery system approach. The physiological and formulation factors influencing stomach retention time are included in the latest advancements in floating drugs delivery systems. Bringing together the most recent research on classification, factors influencing the stomach residence time of floating drug delivery system, and the benefits and drawbacks of application mechanisms of action is the fundamental objective of crafting this review study.