The preformulation study begins with the introduction of a novel chemical. It involves the analysis of physical, chemical, analytical, and medicinal properties related to molecules and provides guidance on suitable alterations to improve molecular efficacy. The examination of preformulation parameters pertains to the creation of effective, safe, stable, and reliable pharmaceutical formulations. Terbutaline is a selective β2 adrenergic receptor agonist often utilised in the acute and long-term management of bronchial asthma, chronic bronchitis, emphysema, and other chronic obstructive pulmonary disorders characterised by reversible bronchial hyperreactivity. Terbutaline sulphate is a short-acting bronchodilator that can be administered orally, parenterally, or by inhalation. The principal objective of the preformulation research of terbutaline is to generate knowledge that facilitates the creation of stable and bioavailable dosage forms.