COVID-19 is a global pandemic declared by WHO, which has contracted more than 500 million people. Existing data on adverse effects of coronavirus disease 2019 (COVID-19) vaccines among university students are limited. This study aimed to investigate the characteristics of adverse effects that may arise from administering COVID-19 vaccines to university students in Saint James School of Medicine. An online survey study was conducted among students from Saint Vincent Campus of SJSM to assess types of adverse effects of COVID-19 vaccines received by the students. Of the 34 participants, 8 (23.5%) received the Johnson & Johnson vaccine, 9 (26.5%) received Moderna, 16 (47.1%) received Pfizer, and one (2.9%) received Sputnik. Pain was the most common adverse effect for both doses, reported by 62.5% of Johnson & Johnson, 50% of Moderna, and 56.3% of Pfizer recipients. Swelling and redness were more frequently reported among Moderna (44.4% and 33.3%) and Pfizer (37.5% and 31.3%) recipients for both doses. Generalized adverse effects like fatigue and muscle aches were also common across doses. Fatigue was reported by 55.6% of Moderna and 37.5% of Pfizer recipients, while muscle aches were noted in 55.6% of Moderna and 46.9% of Pfizer recipients. Most adverse effects occurred within 24-48 hours, were more frequent and severe after the first dose compared to the second and resolved without the need for hospital treatment. Students experienced different adverse effects depending on the type COVID-19 vaccine doses. The effects were generally mild and were less common after the second dose than the first. There is a significant difference for redness in second dose for local reactions when compared between genders.