Background: Chalazion, a common benign eyelid lesion caused by chronic inflammation of a blocked meibomian gland, often requires intervention for larger or recurrent lesions. Incision and curettage (I&C) and intralesional steroid injections are common treatment methods, each with distinct advantages and challenges. This study aims to compare the efficacy, safety, and patient satisfaction of these treatments to guide clinical decision-making. Objective: To evaluate and compare the effectiveness and safety of triamcinolone acetonide (TA) injection, methylprednisolone acetate (Depo) injection, and I&C in the treatment of large chalazia. Methodology: A total of 60 patients with recurrent chalazia were randomly assigned to three treatment groups: TA injection, Depo injection, or I&C. Patients were followed up at 1, 2, and 6 weeks post-treatment. The primary outcome was the complete resolution of the chalazion, defined as an 80% reduction in size with no recurrence. Results: The demographic characteristics, including age and gender, showed no significant differences between groups. The overall success rate for all treatments was 95%, with only 5% of patients in each group experiencing incomplete resolution. A single injection group showed higher success rates (27 successful cases) compared to the two-injection group (13 successful cases), with a statistically significant difference (p < 0.05). Resolution rates improved over time, with 95% complete resolution achieved by 6 weeks in all groups. However, there were no significant differences in resolution rates between groups at any time point (p > 0.05). Conclusion: This study supports that both steroid injections and I&C are highly effective treatments for recurrent chalazions, achieving a 95% success rate. Single injections were more effective than multiple injections. While the resolution rates improved over time, no significant differences were observed between treatment groups. These findings suggest that either treatment option can be selected based on patient preference, with I&C remaining an effective choice for more persistent cases.