Background: ICP is crucial for the occlusal stability and masticatory efficiency. Partial edentulism affects ICP, predisposing to occlusal imbalances, reduced masticatory performance, and increased prevalence of TMJ diseases. Prosthetic rehabilitation includes restoration of functional occlusion, improving patient satisfaction, and improving quality of life. The purpose of this study was to evaluate changes in the intercuspal position by partially edentulous patients after prosthodontic rehabilitation. Methods: This retrospective observational study conducted at Department of Prosthodontics, Bangabandhu Sheikh Mujib Medical University (BSMMU) and beau-dent, Dhaka, Bangladesh from June 2015 to July 2016. Total 100 patients diagnosed with partial edentulism who underwent prosthodontic rehabilitation with complete records documenting pre and post treatment occlusal measurements. The effectiveness of interventions was assessed through statistical analyses such as paired t tests and chi square tests, and the relationship to clinical variables was explored. Results: The ICP mean decreased significantly from 2.0 ± 0.25 to 1.30 ± 0.24 mm (p < 0.001), and the occlusal contact area increased from 19.5 ± 2.6 to 28.3 ± 2.8 mm² (p < 0.001). Removable prostheses were outperformed by fixed prostheses, which improved ICP and occlusal contact. Patients with less missing teeth and shorter duration of edentulism had better outcomes. High satisfaction rates were reported for chewing comfort (75%), improved speech (79%) and prosthesis aesthetics (79%). Conclusion: In partially edentulous patients, prosthetic rehabilitation can substantially improve ICP, occlusal contact area, and patient satisfaction. The findings also support individualized treatment and early intervention to maximize outcome.