The halal lifestyle is now widely adopted in Muslims' lives, including medical practice. The study aims to determine the level and correlation of knowledge, perception, and attitude of doctors toward readiness to enter the era of mandatory halal certification of drugs and the demographic factors that influence it. A cross-sectional study was conducted online using a questionnaire validated by experts and previous validation and reliability tests. This study was attended by 400 respondents from five provinces in Java, using purposive sampling. The results of the study showed that doctors had sufficient knowledge (mean 38.50 ± 2.293), sufficient perception (mean 40.92 ± 5.076), and sufficient attitude (mean 39.14 ± 4.523) towards halal drugs. There is a weak correlation between knowledge perception (r=0.306, p<0.05), a very weak correlation between knowledge attitude (r=0.297, p<0.05), and a robust correlation between perception attitude (r=0.828, p<0.05). Doctors' knowledge, perception, and attitudes about halal medicine influence each other (p value<0.05). Factors such as workplace, position, and length of service influence knowledge (p value<0.05), and age, workplace, position, and length of service influence perception and attitude (p value<0.05.) of doctors about halal medicine. It is concluded that doctors have sufficient knowledge, perception, and attitude and influence each other; the correlation between knowledge-perception is weak, knowledge-attitude is very weak, and perception-attitude is very strong. Age has a relationship with knowledge, perception, and attitude, education has a relationship with knowledge, and the workplace has a relationship with doctors' perception of halal medicine.