Epilepsy requires a constant medication during pregnancy. Maintaining, monitoring and a stability of pregnant women with epilepsy between restricting seizures and reducing fetal exposure to the antiepileptic drugs are essential. Major and minor malformations were presented in children subjected to the antiepileptic drugs during pregnancy. This review article aimed to highlight some of antiepileptic drugs as potential teratogen to understand the associated congenital malformation risks with these drugs, differences in hazards between several selection treatment are essential to safe both mother and fetus.