Background: Sickle cell disease (SCD) is an autosomal recessive disease characterized by production of abnormal hemoglobin S. The aim of this study is to review the history of SCD adults patients who were admitted to inpatient ward in Al-Ahsa, Saudi Arabia. Method: A retrospective cross sectional study was conducted through medical records chart review in King Fahad Hospital (KFH) in Al Ahsa to detect all SCD adults patients who were admitted to inpatient ward during 2013 to 2015. A structured Self designed questionnaire was reviewed and used during data collection from patients files. Results: A total of 130 patients were admitted to inpatient ward, consanguinity reported in 96.2 %. In the last visit, 64.3 % had diagnosed with vaso-occlusive crises, 10.1 % had sequestration crises, 13/2 % had acute chest syndrome, and 12.4% had gall stone. Complications of SCD included spleen removed (46.4%), infection (93%), anemia (93%) and acute chest syndrome (40.6%). Conclusion: SCD is considered as a load in the secondary health care services. Further studies need to be conducted in this subject.