Background: Optic Disc Drusen (ODD) are calcified deposits in the optic nerve head and may be implicated in Nonarteritic Anterior Ischemic Optic Neuropathy (NAION), particularly in younger patients. NAION typically affects older individuals but is occasionally seen in younger populations, where ODD may contribute to its pathogenesis. In regions like Bangladesh, the prevalence of ODD in younger NAION patients is underreported, making it essential to explore this association further. Objective: To assess the prevalence of ODD in young patients diagnosed with NAION in Bangladesh and explore its clinical significance. Methods: This retrospective study reviewed medical records from two tertiary care centers in Bangladesh over a 10-year period (2009–2019). Patients aged 18–50 diagnosed with NAION were included, and the presence of ODD was determined using various imaging modalities such as enhanced-depth imaging optical coherence tomography (EDI-OCT), fundus autofluorescence (FAF), computed tomography (CT), and ultrasound (US). The prevalence of ODD in NAION-affected eyes was calculated, and statistical analyses compared the presence of ODD with patient demographics and NAION characteristics. Results: ODD was detected in 53.3% of NAION-affected eyes and 56.7% of young NAION patients. EDI-OCT showed the highest sensitivity (54.2% detection in eyes and 58.3% in patients). Most ODD were bilateral (95.2%), with 20% of these patients also presenting with bilateral NAION. There was no significant difference in sex or age of onset between patients with and without ODD. Conclusion: The study reveals a high prevalence of ODD in young NAION patients in Bangladesh, suggesting a strong association between ODD and NAION in this demographic. The results emphasize the importance of using advanced imaging modalities like EDI-OCT for accurate diagnosis. Future research should investigate whether ODD is an independent risk factor for NAION in young patients.