Objectives: To assess the data on smoking's role as an irritable bowel syndrome (IBS) risk factor. Methods: Electronic databases including PubMed, Science Direct, Cochrane Library, and Scopus were thoroughly searched. Qualifying papers were assessed and data was extracted by two impartial reviewers. Results: Our data consists of eight studies with 1458 children, 864 (59.3%) of whom were female. All of the included studies used ROME criteria for IBS diagnosis. The prevalence of smoking among IBS patients ranged from 3.8% to 37%, with a total prevalence of 405 (27.8%). Five studies have demonstrated that the incidence of IBS was not significantly correlated with cigarette smoking. Two studies reported that smoking was a significant risk factor for IBS incidence and one found that IBS-M was the only variant related to smoking. Conclusion: There is still no obvious connection between smoking and irritable bowel syndrome because the analyzed research produced inconsistent results. While some studies indicate that smoking may worsen the symptoms of IBS or raise the likelihood of getting the condition, other research rejects this link. Clinicians should keep encouraging smoking cessation due to its many health benefits until more conclusive data is available, but they should also be open to the potential that it could improve the outcomes of IBS patients. To reconcile these contradictory results and get a deeper comprehension of the possible contribution of smoking to the etiology of IBS, more investigation is required.