Background: Obesity is a growing global health issue with significant implications for gynecological health. This study investigates the impact of obesity on various gynecological outcomes, comparing obese and non-obese women. Methods: A cross-sectional comparative study was conducted at BSMMU and Dhaka Medical College from February 2022 to January 2023. A total of 150 female participants were purposively selected and divided into two groups: Group 1 (Obesity, n=75) and Group 2 (No Obesity, n=75). Data on blood pressure, HbA1c levels, body fat percentage, waist circumference, cholesterol levels, physical activity, insulin sensitivity, sleep duration, and the prevalence of complications such as hypertension, diabetes, sleep apnea, and joint pain were collected and analyzed. Result: Obese participants had significantly higher blood pressure (140 ± 10 mmHg vs. 125 ± 8 mmHg, p=0.002), HbA1c levels (7.2 ± 1.1% vs. 5.9 ± 0.8%, p=0.004), body fat percentage (35 ± 5% vs. 22 ± 4%, p=0.001), and waist circumference (110 ± 12 cm vs. 85 ± 10 cm, p=0.003) compared to non-obese participants. Additionally, obese women exhibited a higher prevalence of hypertension (27% vs. 13%, p=0.045), diabetes (20% vs. 7%, p=0.032), sleep apnea (16% vs. 5%, p=0.021), and joint pain (24% vs. 11%, p=0.039). Conclusion: The study highlights the detrimental effects of obesity on gynecological health, emphasizing the need for effective weight management strategies to improve reproductive health outcomes and overall well-being in women.