Background: Coronary arteries and their variation in branching patterns have a significant role in cardiac deaths in recent years. Aim: To study the branching patterns of the human coronary arteries and their clinical importance. Materials and Methods: A total of 40 Human heart specimens were collected from the Department of anatomy, Santhiram Medical College, Nandyal to study the branching patterns of human coronary arteries and their clinical importance. The variations in branching patterns like Trifurcation, Quadrifurcation of the coronary arteries were noted in the present study. Results: The termination of left coronary artery showed a branching pattern as bifurcation in 29 (72.5%) specimens, Trifurcation in 6(15%), Quadrifurcation in 5(12.5%) out of 40 specimens in our study. We observed 28% of the variations in branching patterns of left coronary artery, whereas right coronary artery branching pattern was normal in the present study. Conclusion: Various branching patterns of coronary arteries should be acknowledged during the catheterization for coronary angiography.