Sarcoidosis is an uncommon chronic multisystemic fibro-inflammatory disease of unknown aetiology, characterized histologically by the presence of non-caseating granuloma. We report the 15th case of isolated splenic sarcoidosis in a 71-year-old Nigerian female, which was discovered incidentally while being managed for acute intestinal obstruction due to volvulus. Abdominal ultrasound scan revealed a large multinodular spleen. Open splenectomy was performed and the diagnosis of splenic sarcoidosis was confirmed histologically. Her post-operative condition has been stable. Sarcoidosis should always be considered in isolated nodular splenomegaly with or without symptoms.