Alchornea cordifolia extract is widely used as ethnomedicine in Ivory coast to treat various ailments related to bacterial, fungal, parasitic and inflammatory disorders, infertility problems, among other. Here, the objective was to evaluate some long lasting neuroprotective properties of Alchornea cordifolia extract against a rat’s model of LPS-induced early-life neuroinflammation. The neuroinflammation was induced with a single dose of LPS (1mg/kg, i.p) in neonatal rats (postnatal day 4) or PBS rats (1ml/100g, vehicle). Six hours later, some LPS rats were treated either with minocycline (50 mg/kg, i.p) or Alchornea cordifolia extract (200 or 400 mg/kg, p.o) for 14 consecutive days. Then, rats were followed carefully till adulthood (P 90) for the evaluation of cognitive behavioral status and oxidative damage level in hippocampus and prefrontal cortex. Results showed that the treatment with Alchornea cordifolia extract (200 or 400 mg/kg) attenuated LPS-induced deficits of spatial learning and memory (Y-maze and Morris water maze) and recognition memory (Object recognition test). However, only dose of 200 mg/kg of Alchornea cordifolia extract reduced significantly lipid peroxidation through MDA content and enhanced the enzymatic antioxydant SOD level in hippocampus and prefrontal cortex. On the whole, the threshold dose 200 mg/kg of Alchornea cordifolia demonstrated long lasting beneficial neuroprotective effects against LPS-induced early-life neuroinflammation incomparable to reference molecule minocycline. This findings suggest that Alchornea cordifolia rich in quercitrin bioactive need further biochemical and histopathology studies before promising as efficient therapeutic agent against neurodegenerative and psychiatric diseases.