The study is an ecotoxicological evaluation of commercial fish farm in Ogbogoro (OGB), Rivers State Nigeria using anatomical/macro morphological assessment of Clarias gariepenus, and African Aquaculture Centre (ARAC) as a the reference site. The sampling involved harvesting of table-sized fish: twenty fishes from OGB and ten fishes from ARAC. The gross anatomy (fish necropsy) involved the determination of Fish Biometry (Condition factor, CF and Organosomatic Indices, OSI) and Health assessment index (HAI). Showed that: fishes from OGB were less healthy based on the CF; OGB were less Healthier based on OSI; OGB fishes were less Healthier based on HAI when compared to fishes from ARAC. It was concluded from the study that the fishes from Ogbogoro fish farm had certain level of pollution though considered to be moderate at the time of the study.